Mefloquine as a potential drug against multidrug-resistant tuberculosis
نویسندگان
چکیده
Support statement: This work was supported by the State of New Mexico (appropriation from the Tobacco Settlement Fund), from the National Institutes of Health (P50HL107165 for B. Celli and Y. Tesfaigzi, RO1 HL068111 and ES015482 to Y. Tesfaigzi, R01CA164782 for Y. Tesfaigzi/S.A. Belinsky, R01 CA097356 for S.A. Belinsky, HL105339, HL114501, AI111475 for C.A. Owen, FAMRI CIA 123046 for C.A. Owen) and funds from GSK. Funding information for this article has been deposited with FundRef.
منابع مشابه
Mefloquine as a potential drug against multidrug-resistant tuberculosis.
In the article by ALSAAD et al. [1] in a recent issue of the European Respiratory Journal the authors reviewed six drugs with antimicrobial activity against Mycobacterium tuberculosis (phenothiazine, metronidazole, doxycycline, disulfiram, tigecycline and co-trimoxazole) which are not listed in the World Health Organization guidelines on multidrug-resistant tuberculosis (MDR-TB) treatment, but ...
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Objective. Tuberculosis is a serious problem of public health. The increase on the number of clinical cases of tuberculosis infected with multidrug resistant (MDR) M. tuberculosis calls for the development of novel therapy. Design. We investigated the effect of mefloquine and two enantiomers, (+)erythro-mefloquine and (+)threo-mefloquine against M. tuberculosis strains in the environment resemb...
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Patient noncompliance to current tuberculosis (TB) therapy owing to multidrug administration daily leads to treatment failure and emergence of multidrug resistant and extensively drug resistant TB. To avoid the daily dosing, application of nanotechnology is the only viable solution by virtue of sustained release of drugs. Other potential advantages of the system include the possibility of selec...
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Patient noncompliance to current tuberculosis (TB) therapy owing to multidrug administration daily leads to treatment failure and emergence of multidrug resistant and extensively drug resistant TB. To avoid the daily dosing, application of nanotechnology is the only viable solution by virtue of sustained release of drugs. Other potential advantages of the system include the possibility of selec...
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